Estimate how much weight and body fat you may gain from antidepressant use based on your medication type, dose, and duration.
Medical Disclaimer: This tool provides general educational estimates. Always consult your prescribing physician or healthcare provider before making medication changes or interpreting results from population-based models.
Learn how antidepressants influence fat storage, appetite, and metabolism. Read the full Antidepressant & Body Fat Guide →
This calculator estimates potential weight and body fat changes associated with antidepressant medications based on clinical research data. Here's how to use it:
The results show your estimated weight gain, potential body fat percentage increase, and a risk level classification based on clinical data.
Remember: This calculator provides estimates based on population averages. Individual responses to medications vary widely based on genetics, lifestyle, concurrent medications, and other factors.
Clinical studies show that mirtazapine (Remeron), paroxetine (Paxil), and tricyclic antidepressants like amitriptyline (Elavil) are associated with the highest rates of weight gain. Bupropion (Wellbutrin) is often weight-neutral or associated with mild weight loss for some patients. SSRIs like fluoxetine (Prozac) and sertraline (Zoloft) typically have moderate weight effects.
Yes. Weight gain includes all body mass (muscle, water, bone, and fat), while body fat percentage specifically measures adipose tissue increase. Research suggests antidepressants may particularly affect fat distribution, with many patients experiencing increases in visceral (abdominal) fat even when total weight changes are modest. This calculator estimates both weight changes and potential body fat percentage increases.
The timing pattern varies by medication, but typically shows minimal changes in the first 4-8 weeks, with more significant changes occurring between months 2-6 of treatment. Some medications (particularly mirtazapine and TCAs) may cause earlier changes. Many patients report that weight tends to stabilize after 6-12 months of continuous treatment.
This calculator uses data from peer-reviewed clinical studies on antidepressant-associated weight changes, but individual outcomes vary considerably based on many factors. The estimates provide educational information only and should not replace medical advice. Always consult with your healthcare provider before making any decisions about medication.
Some research suggests that regular physical activity (150+ minutes weekly), higher protein intake (20-30% of calories), and focus on nutrient-dense foods may help mitigate medication-associated weight changes. For patients with significant concerns, physicians may sometimes consider medication adjustments or combinations to minimize metabolic effects while maintaining therapeutic benefit.